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Berberine improves insulin sensitivity directly through AMPK activation and GLUT4 upregulation at the cellular membrane level

Because it is still in the clinical trial phase globally, its long-term safety profile and benefit-risk balance are still being evaluated

The relatively small number of patients on FDA-approved medications limits the strength of direct formulation comparisons

382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms

Phentermine is an anorectic or appetite suppressant that works by decreasing hunger and making you feel full longer